Psicothema was founded in Asturias (northern Spain) in 1989, and is published jointly by the Psychology Faculty of the University of Oviedo and the Psychological Association of the Principality of Asturias (Colegio Oficial de Psicólogos del Principado de Asturias).
We currently publish four issues per year, which accounts for some 100 articles annually. We admit work from both the basic and applied research fields, and from all areas of Psychology, all manuscripts being anonymously reviewed prior to publication.

  • Director: José Muñiz
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  • ISSN: 0214-9915
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  • Address: Ildelfonso Sánchez del Río, 4, 1º B
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Psicothema, 2009. Vol. Vol. 21 (nº 3). 416-420

Executive function and memory in patients with relapsing-remitting multiple sclerosis

Marta Cerezo García, Pilar Martín Plasencia, Yolanda Aladro Benito*, José Jesús Balseiro Gómez* and Almudena Rueda Marcos*

Universidad Autónoma de Madrid and * Hospital Universitario de Getafe

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system very heterogeneous in its characteristics. In contrast to the well known sensitive/motor deficits, the cognitive dysfunction has only been analyzed in the last few decades. Attention, executive function, and memory were assessed in 28 patients with recurrent-remittent MS (RRMS) (duration, median 7 years; EDSS median 2) by means of a specific neuropsychological battery. Depression (BDI), anxiety (STAI) and fatigue (FSS) were also assessed. Twenty-five of these patients were selected for statistical study because they presented deficits in some cognitive areas. Twenty-four percent of the patients displayed memory deficits and 80% showed attention and executive function deficits related to prefrontal lobe function. No global memory difficulties were found, except for immediate visual memory of complex elements (immediate recall of the Rey figure), although the visual reproduction I subtest of the WMS-R was unaffected. In RRMS patients with a relatively short duration and low level of incapacity, cognitive impairments mainly affected prefrontal functions. The difficulties in immediate visual memory of complex elements could also be explained by a failure in these areas, due to the alteration of the organization and strategic use of the material to be encoded.

Función ejecutiva y memoria en pacientes con esclerosis múltiple recurrente-remitente. La esclerosis múltiple (EM) es una enfermedad inflamatoria crónica del sistema nervioso central muy heterogénea en sus manifestaciones. A diferencia de los déficits sensitivos-motores, muy bien estudiados, los aspectos cognitivos están siendo analizados sólo en las últimas décadas. A 28 pacientes con EM recurrente-remitente (EMRR) (tiempo de evolución, mediana 7 años; EDSS, mediana 2) se les realizó una evaluación de atención, función ejecutiva y memoria mediante una batería neuropsicológica específica. Se evaluaron también el grado de depresión (BDI), ansiedad (STAI) y fatiga (EGF). Veinticinco fueron seleccionados para el estudio por presentar alteración en algún aspecto cognitivo. El 24% mostraba disminución en memoria y el 80% en atención y funciones ejecutivas relacionadas con regiones prefrontales. No se observaron dificultades globales de memoria, salvo en memoria inmediata visual de elementos complejos (Figura de Rey reproducción inmediata), sin afectarse la prueba de reproducción visual I de la WMS-R. En pacientes con EMRR con un tiempo medio de evolución y bajo nivel de incapacidad, las alteraciones cognitivas afectan fundamentalmente a funciones atribuidas a regiones prefrontales. Las dificultades en memoria inmediata visual de elementos complejos se explicarían también por un fallo de estas áreas al alterarse la organización y uso estratégico del material a codificar.


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