INFORMATION

Psicothema was founded in Asturias (northern Spain) in 1989, and is published jointly by the Psychology Faculty of the University of Oviedo and the Psychological Association of the Principality of Asturias (Colegio Oficial de Psicólogos del Principado de Asturias).
We currently publish four issues per year, which accounts for some 100 articles annually. We admit work from both the basic and applied research fields, and from all areas of Psychology, all manuscripts being anonymously reviewed prior to publication.

PSICOTHEMA
  • Director: José Muñiz
  • Frequency:
         February | May | August | November
  • ISSN: 0214-9915
  • Digital Edition:: 1886-144X
CONTACT US
  • Address: Ildelfonso Sánchez del Río, 4, 1º B
    33001 Oviedo (Spain)
  • Phone: 985 285 778
  • Fax: 985 281 374
  • Email:psicothema@cop.es

Psicothema, 2009. Vol. Vol. 21 (nº 3). 471-474




Lidocaine, tetrodotoxin and their effect on consolidation of spatial memory

José Manuel Cimadevilla, Francisco López, Luz Nieto, Mª Jesús Aguirre and Rubén Fernández

Universidad de Almería

This study was aimed at comparing the effect of unilateral hippocampal inactivation with tetrodotoxin (TTX) and lidocaine on spatial memory consolidation. Both drugs block voltage-dependent sodium channels. However, TTX and lidocaine differ in the duration of their effects, with maximum TTX effect between 30 min and 120 min, washing out in 24 hours. Lidocaine maximum effect occurs 20-30 minutes after administration. Our experimental subjects, twenty-four 3-month-old Wistar rats, were unilaterally implanted with stainless-steel cannulae aimed at the right dorsal hippocampus. Animals received four daily trials for 5 consecutive days. Control injections of 1 µl saline, or inactivating injections of 5ng of TTX in 1 µl saline or lidocaine (2%) in 1 µl were made through a guide cannula 1 minute after the last trial from day 1 to day 4. Results showed that the groups that received TTX or lidocaine did not differ but were impaired regarding controls, suggesting that short-term consolidation processes can account for the memory impairment observed here.

Lidocaína, tetrodotoxina y su efecto sobre la consolidación de la memoria espacial. El objetivo de este estudio ha sido comparar el efecto de la inactivación unilateral del hipocampo con tetrodotoxina (TTX) o lidocaína sobre la consolidación de la memoria espacial. Ambas drogas bloquean los canales de sodio dependientes de voltaje, pero difieren en la duración de sus efectos, mostrando la tetrodotoxina su máxima actividad entre 30 y 120 minutos, eliminándose completamente a las 24 horas. En cambio, el máximo efecto de la lidocaína acontece entre 20-30 minutos tras su administración. Nuestros sujetos experimentales fueron canulados unilateralmente sobre hipocampo dorsal. Los animales recibieron cuatro ensayos diarios durante 5 días consecutivos. Las inyecciones control de 1 µl de un compuesto salino, o inyecciones inactivadoras de 5ng de TTX en 1 µl de salino o lidocaína (2%) en 1 µl de salino, se aplicaron a través de una cánula guía 1 minuto después del último ensayo desde los días 1 al 4. Los resultados mostraron que los grupos que recibieron TTX o lidocaína no difieren entre ellos en sus efectos, pero en cambio resultaron perjudicados en comparación con el grupo control, lo que sugiere que los procesos de consolidación a corto plazo pueden explicar la alteración mnésica que se observa en este trabajo.

PDF

Impact factor 2021:   JCR (WOS): 3.890 (Q1)   |   SJR (Scopus) : 1.308 (Q1)    |  CiteScore 2020: 5,3

Psicothema is included in the following documentation Centers:
Social Sciences Citation Index JCR WOS. Current Contents - Social and Behavioural Sciences. MEDLINE/Index Medicus. Index Copernicus. Psychological Abstracts. PsycLIT. PsycINFO. Family Studies Database. Bases de datos ISOC–Psicología. REDINED. Psicodoc. Scopus. Dialnet. IN-RECS, Latindex, Redalyc, Google Scholar, European Reference Index For The Humanities, Directory of open access journals, Pubpsych, IBECS (Spanish bibliographic index in health sciences) and REDIB


CONTACT US

Ildelfonso Sánchez del Río, 4, 1º B
33001 Oviedo · Spain

   985 285 778    Contact

Legal Warning | Cookies | Privacy policy

SCImago Journal & Country Rank