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Psicothema, 2009. Vol. Vol. 21 (nº 4). 528-530

The effect of amitriptyline on inhibitory avoidance in mice is dose-dependent

Andrés Parra, Concepción Vinader-Caerols, Aránzazu Ferrer-Añó, Adoración Urquiza and Santiago Monleón

Universidad de Valencia

The purpose of the present work was to study the dose-effect relationship of the antidepressant amitriptyline on inhibitory avoidance in male and female mice. Subjects received physiological saline or 2.5, 5, 10 or 20 mg/kg of amitriptyline hydrochloride 30 min before the training phase, and were subjected to the test phase 24 h later. Results showed a clear impairing effect of amitriptyline on inhibitory avoidance in both male and female mice, and that the effect is dose-dependent.

El efecto de la amitriptilina sobre la evitación inhibitoria en ratones es dependiente de dosis. El propósito del presente trabajo fue estudiar la relación dosis-efecto del antidepresivo amitriptilina sobre la evitación inhibitoria en ratones machos y hembras. Los sujetos recibieron suero salino o 2.5, 5, 10 ó 20 mg/kg de clorhidrato de amitriptilina 30 min antes de la fase de entrenamiento, y fueron sometidos a la fase de test 24 h más tarde. Los resultados mostraron un claro efecto deteriorante de la amitriptilina sobre la evitación inhibitoria tanto en los ratones machos como en las hembras, y que el efecto es dependiente de dosis.


Impact factor 2022:  JCR WOS 2022:  FI = 3.6 (Q2);  JCI = 1.21 (Q1) / SCOPUS 2022:  SJR = 1.097;  CiteScore = 6.4 (Q1)